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To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

A radiometric assay was performed by RBC using 100M5 nM SAH as an inhibitor positive control

These species are termed free radicals

Karanth School of Health Professions and Human Services, Hofstra University, Hempstead, NY, USA Ibraheem M

Recent studies have revealed alteration in the status of post-translational modifications, such as phosphorylation and methylation, in the promoters of the core clock genes in cancerous tissues, leading to the deregulation of clock gene expression 98,99